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A 40 - year - previous man with a tender pharynx and fever was diagnosed with tonsillitis , and was prescribedpenicillin , a common antibiotic . But several days afterwards , the man developed a roseola over his armpits , groin and stern — an strange precondition known as " baboon syndrome . "
The circumstance , more formally called symmetrical drug - have-to doe with intertriginous and flexural exanthema ( SDRIFE ) , is known as baboon syndrome because therashon the patient ’s can resembles the cherry hindquarters of some monkeys .
Baboon syndrome is a rare rash that appears on the buttocks, but can also appear in the armpits and other areas too.
Because doctor oftenprescribe penicillin antibioticsto treat tonsillitis and other bacterial infections , it is of import to be aware that baboon syndrome is one of the medication ’s potential side effects , wrote the researchers who reported the man ’s case online Nov. 28 in the journal BMJ Case Reports .
The condition is unremarkably make by an allergic reaction to penicillin drug , but can also be due to vulnerability to mercury or Ni , order Dr. Andreas Bircher , a dermatologist at University Hospital of Basel in Switzerland . ( He was not involved in the study but has report other pillow slip of baboon syndrome . )
In the present cause , during the man ’s initial interrogation , he had enlarged and inflamedtonsils , accord to the physicians at the NHS Lothian hospital in the United Kingdom who report the fount . His veritable doctor had prescribed penicillin for him two sidereal day earlier , but the patient became ineffectual to eat up . [ 8 Strange Signs You ’re Having an Allergic chemical reaction ]
The emergency - section doctor who saw the humankind started him on a course of study of endovenous benzylpenicillin ( a dissimilar type than the oral penicillin ) four times a day and give him a single dose of endovenous dexamethasone , a steroid medication used to treat firing .
By the next day , the patient had developed a roseola over his groins and interior cubital joint . acquire it was a reaction to the penicillin , the doctor change his antibiotic to clarithromycin ( which is in a different class of antibiotics ) .
On the third Clarence Day after being catch at the infirmary , the patient ’s pharynx was much good , and he was able to swallow up liquids and soft foods , but his skin rash had spread and become sore . At that full stop , the rash overcompensate his armpit , buttocks , scummy abdomen and upper thighs , and his mole show house of necrosis ( idle tissue ) .
The doctors had to determine whether the patient role was having a severe drug reaction , which would get better on its own , or a life-threatening contagion offlesh - eating bacteria(necrotizing fasciitis ) , which would require immediate removal of the dead or infected tissue paper .
The squad started the patient on non - penicillin broad - spectrum antibiotics , which playact against a stove of bacteria , and took a tissue sampling from his good groin . The sample test electronegative for flesh - eat bacteria , so the patient role was diagnosed with baboon syndrome .
" It ’s not a very common condition , " Bircher told LiveScience . For unnamed reason , it ’s more rife in male , and usually seen in postpubescent people .
The patient stopped taking antibiotic , and used oral and topical steroids to cover his efflorescence . He was discharged from the hospital 11 mean solar day after being admit , and the efflorescence disappeared .
" It ’s a lawful allergic reaction , " Bircher said . With steroid treatment , the efflorescence usually fades within a week , but re - exposure to the drug or allergen can cause a reversion within one to two solar day , Bircher sound out .
Baboon syndrome typically appear a few hours to two day after a soul train an antibiotic drug . The syndrome rarely affects small fry , but cases have been reported in an 18 - month - former and a 5 - year - onetime , the researchers note in their compositor’s case report . recuperation can sometimes take up to three weeks .
Exposure to penicillin , nickel or Hg are the most uncouth causes of the syndrome , but it has also been linked to certain pyrosis drug , biological agent and chemotherapy .
